Does pernicious anemia cause joint pain?

Multiple Autoimmune Conditions

A 2021 report in the journal Nature Communications reported that up to 55.8% of people with pernicious anemia have at least one other autoimmune disorder. 9 Up to 40% of people with PA also have rheumatoid arthritis—a condition caused by similar inflammatory processes to PsA.

Can pernicious anemia cause arthritis?

No clear association exists between pernicious anemia and rheumatoid arthritis in the medical literature though RA has been associated with other autoimmune conditions. Anemic patients with rheumatoid arthritis most commonly exhibit anemia of chronic disease or iron deficiency anemia [21].

Can pernicious anemia cause rheumatoid arthritis?

In a study of 99 patients with pernicious anaemia the incidence of clinical rheumatoid arthritis was normal but rheumatoid factor was present significantly more often than in controls.

What autoimmune disease is related to pernicious anemia?

Common causes of pernicious anemia include: weakened stomach lining (atrophic gastritis), an autoimmune condition in which the body's immune system attacks the actual intrinsic factor protein or the cells in the lining of your stomach that make it.

What part of the body does pernicious anemia affect?

Pernicious anaemia is an autoimmune condition that affects your stomach. An autoimmune condition means your immune system, the body's natural defence system that protects against illness and infection, attacks your body's healthy cells. Vitamin B12 is combined with a protein called intrinsic factor in your stomach.

Pernicious Anemia: a Rare Cause of Radiating Upper and Lower Extremity Pain

How does pernicious anemia make you feel?

These symptoms include nausea (feeling sick to your stomach) and vomiting, heartburn, abdominal bloating and gas, constipation or diarrhea, loss of appetite, and weight loss. An enlarged liver is another symptom. A smooth, thick, red tongue also is a sign of vitamin B12 deficiency and pernicious anemia.

What can be mistaken for pernicious anemia?

Pernicious anemia with spuriously normal vitamin B12 level might be misdiagnosed as myelodysplastic syndrome.

What is the typical appearance of patients with pernicious anemia?

Typically, patients with pernicious anemia are described as having a stereotypic appearance: they have a lemon-yellow waxy pallor with premature whitening of the hair, and they appear flabby, with a bulky frame that is generally incongruent with the severe anemia and weakness.

Does pernicious anemia affect your bones?

Pernicious anemia has recently been recognized as a risk factor for osteoporosis and fractures. Although vitamin B12 is important for osteoblast function, the effect of vitamin B12 replacement in states of vitamin B12 deficiency on bone density and fracture incidence is not known.

Can pernicious anemia cause other health problems?

People with pernicious anemia may have gastric polyps. They are also more likely to develop gastric cancer and gastric carcinoid tumors. People with pernicious anemia are more likely to have fractures of the back, upper leg, and upper forearm.

What vitamin deficiency can cause joint pain?

Vitamin D status influences musculoskeletal health. Low vitamin D levels may lead to clinical manifestations, including bone pain, muscle weakness, falls, low bone mass, and fractures, with subsequent diagnoses of osteomalacia, osteoporosis, and myopathy.

Does B12 shots help with joint pain?

Vitamin B12 specifically is a vitamin for nerves and joints – it protects the nerves, stimulates nerve regeneration, and could help reduce the pain from old injuries.

Can low B12 cause aching legs?

B12 deficiency affects sensory nerve function leading to motor dysfunction, which can cause muscle cramps and weakness.

What does B12 deficiency pain feel like?

a sore and red tongue (glossitis) mouth ulcers. pins and needles (paraesthesia) changes in the way that you walk and move around.

Does pernicious anemia show up on a CBC?

A test called a complete blood count (CBC) can often provide some key clues. In someone with pernicious anemia, these tests can show a reduced number of functioning red blood cells in the body.

Does pernicious anemia show up in blood test?

Blood tests and procedures can help diagnose pernicious anemia and find out what's causing it.

Would a full blood count show pernicious anemia?

A full blood count - to see if anaemia is affecting the production of your red blood cells. Methylmalonic acid (MMA) - to confirm B12 deficiency and intrinsic factor antibodies to identify whether pernicious anaemia could be caused by an autoimmune condition.

How often should you have B12 injections for pernicious anemia?

If your vitamin B12 deficiency is not caused by a lack of vitamin B12 in your diet, you'll usually need to have an injection of hydroxocobalamin every 2 to 3 months for the rest of your life.

Does pernicious anemia cause back pain?

Nerve pain can also be exacerbated by or as a result of illnesses like pernicious anemia (vitamin B12 deficiency) or diabetes, something we call neuropathic pain or neuralgia and pain tends to be described as burning, sharp, stabbing, tingling or like an electric shock.

Why am I still tired after B12 injections?

More Serious Effects

B12 injections may contribute to low potassium levels in your body. Though rare, this reaction can cause muscle cramping, extreme fatigue, and an irregular heartbeat.

Who is most at risk for pernicious anemia?

Pernicious anemia is more common in people of Northern European and African descent than in other ethnic groups. Older people also are at higher risk for the condition. This is mainly due to a lack of stomach acid and intrinsic factor, which prevents the small intestine from absorbing vitamin B12.

Is pernicious anemia hard to diagnose?

Although safe and effective therapy is available and the management of PA is straightforward, the diagnosis of PA can be extremely difficult to obtain due to myriad and diverse clinical presentations, frequently coexisting diseases, and limitations of currently available diagnostic tests.

What is pernicious anemia called now?

Pernicious anemia/megaloblastic anemia. In: Kellerman RD, Rakel DP, eds. Conn's Current Therapy 2022. Philadelphia, PA: Elsevier; 2022:464-466.