Does metformin cause leg aches?

Among patients taking both statins and metformin, just 35% reported muscle cramps and 40% reported leg or calf pain while walking.

Does metformin cause leg pain and weakness?

Many of the warning signs are similar to some metformin side effects, like stomach pain, dizziness, and weakness. Others are numbness or a cold feeling in your limbs, or changes in your heart rate. Call your doctor right away if you notice any of these problems.

Does metformin cause aches and pains?

Conclusions: People with diabetes taking metformin were less likely to report back, knee, neck/shoulder and multisite musculoskeletal pain than those not taking metformin. Therefore, when treating these patients, clinicians should be aware that metformin may contribute to fewer reports of musculoskeletal pain.

Can metformin affect your muscles?

Conclusions. Our results demonstrate that metformin treatment impairs muscle function through the regulation of myostatin in skeletal muscle cells via AMPK‐FoxO3a‐HDAC6 axis.

What are the two most common side effects of metformin?

The most common side effects of metformin include: heartburn. stomach pain. nausea or vomiting.

Metformin Side Effects (

What is the most serious side effect of metformin?

Under certain conditions, too much metformin can cause lactic acidosis. The symptoms of lactic acidosis are severe and quick to appear, and usually occur when other health problems not related to the medicine are present and are very severe, such as a heart attack or kidney failure.

What should I avoid while taking metformin?

Other things to avoid while on metformin

diuretics, such as acetazolamide. corticosteroids, such as prednisone. blood pressure medication, such as amlodipine (Norvasc) anticonvulsants, such as topiramate (Topamax) and zonisamide (Zonegran)

Does diabetes cause muscle pains?

Symptoms of diabetes-related musculoskeletal problems include muscle pain, joint pain or stiffness, lessened ability to move your joints, joint swelling, deformities, and a “pins and needles” sensation in the arms or legs. Some musculoskeletal problems are unique to diabetes.

What is the long term effect of taking metformin?

The most serious of these is lactic acidosis, a condition caused by buildup of lactic acid in the blood. This can occur if too much metformin accumulates in the blood due to chronic or acute (e.g. dehydration) kidney problems. Severe acute heart failure, or severe liver problems can also result in a lactate imbalance.

What is the best time of day to take metformin?

Metformin alone: At first, 500 milligrams (mg) two times a day taken with the morning and evening meals, or 850 mg a day taken with the morning meal. Your doctor may increase your dose if needed until your blood sugar is controlled.

What does diabetic leg pain feel like?

Another symptom is a burning, sharp, or aching pain (diabetic nerve pain). The pain may be mild at first, but it can get worse over time and spread up your legs or arms. Walking can be painful, and even the softest touch can feel unbearable. Up to 50 percent of people with diabetes may experience nerve pain.

Why do legs hurt with diabetes?

Leg pain and cramps often occur as a result of nerve damage called diabetic neuropathy. If diabetes damages nerves in your arms or legs, it's called diabetic peripheral neuropathy. This condition can be a direct result of long-term high blood sugar levels (hyperglycemia) in those who have diabetes.

Does diabetes affect your leg muscles?

Patients with type 2 diabetes have muscle weakness in more areas of the leg than previously thought, according to new research. It is well known people with diabetes can suffer from muscle weakness of the lower limbs, such as the calf muscle, which increases the risk of falling.

Why do my legs ache every night?

Vein issues

This means the veins aren't working as well as they should, so over the course of the day, the pressure in your leg can increase from leaky valves or weakened vein walls. This creates an aching pain and heavy feeling in your legs, which worsens at night after a day spent mostly on your feet.

Does metformin cause muscle fatigue?

If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the ...

What can cause leg pain and weakness?

How many years can you stay on metformin?

Generally, if you are prescribed metformin, you will be on it long term. That could be many decades, unless you experience complications or changes to your health that require you to stop taking it. However, metformin does have some side effects, and patients often have questions about the safety of long-term use.

What is an alternative to metformin?

Precose, Januvia, Victoza, Glucotrol XL, and Actos are some metformin alternatives. Get the full list here. Metformin is an oral prescription medication used in the treatment of Type 2 diabetes mellitus. It belongs to a class of drugs known as biguanides.

What should your blood sugar be when on metformin?

People who don't have diabetes keep their blood sugars between 60 – 100 mg/dl overnight and before meals, and less than 140 mg/dl after meals.

Can diabetes cause severe leg pain?

Some people with diabetes develop a type of nerve damage called diabetic neuropathy. Diabetic neuropathy can cause numbness, tingling, and pain in the feet, and if severe, the legs as well.

What does diabetic legs look like?

Also known as “shin spots,” the hallmark of diabetic dermopathy is light brown, scaly patches of skin, often occurring on the shins. These patches may be oval or circular. They're caused by damage to the small blood vessels that supply the tissues with nutrition and oxygen.

Can too much sugar cause leg pain?

Sugar. Unfortunately, sugar is on top of the list of foods that may increase muscle and joint inflammation. Numerous studies suggest that processed sugars release pro-inflammatory substances in the body, causing further inflammation in the joints.

Can you drink coffee while taking metformin?

Metformin can decrease how quickly the body breaks down caffeine. Taking metformin along with caffeine might increase the effects and side effects of caffeine. MethoxsalenInteraction Rating: Minor Be cautious with this combination. Talk with your health provider.

Can I take vitamin D with metformin?

No interactions were found between metformin and Vitamin D3.

What is the benefit of taking metformin at night?

The administration of metformin, as glucophage retard, at bedtime instead of supper time may improve diabetes control by reducing morning hyperglycemia.