Does hydroxychloroquine cause kidney damage?

Multivariable Analyses

Hydroxychloroquine was associated with a longer time-to-the occurrence of renal damage either in a full (HR=0.12; 95% CI 0.02-0.97) or a reduced (HR=0.29; 95% CI 0.13-0.68) model, after adjusting for confounders as per Table 1.

Is hydroxychloroquine hard on the kidneys?

Cyclosporin, d-penicillamine, and gold are associated with kidney adverse effects, including increased serum creatinine levels, proteinuria, and hematuria (7). In contrast, methotrexate, azathioprine, sulfasalazine, and hydroxychloroquine have relatively little kidney toxicity (5,7).

Is hydroxychloroquine good for kidneys?

1 The authors highlighted that hydroxychloroquine (HCQ) use is recommended for all lupus nephritis patients to reduce risk of kidney flares, end-stage kidney disease (ESKD) and death. The authors also recommended that a reduction of 50% HCQ dose in patients with glomerular filtration rate less than 30 mL/min.

What are the long-term effects of taking hydroxychloroquine?

Long-term use and high doses of hydroxychloroquine are risk factors for the development of cardiomyopathy. Cardiac failure, conduction disorders (including QT prolongation and Torsades de Pointes) and sudden cardiac death are consequences of the cardiomyopathy.

What is the downside of taking hydroxychloroquine?

muscle weakness. unusual bleeding or bruising. bleaching or loss of hair. mood or mental changes.

Hydroxychloroquine And What It Does To Your Body

Who should not take hydroxychloroquine side effects?

Does hydroxychloroquine affect the liver?

Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury.

How long can you be on hydroxychloroquine?

You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness.

How long can you take hydroxychloroquine for rheumatoid arthritis?

Hydroxychloroquine does not seem to confer increased risk when used in patients with rheumatoid arthritis without contraindications in the short term (up to 30 days) compared with sulfasalazine, but confers an increased risk of cardiovascular mortality when used long term.

What is the safest drug for rheumatoid arthritis?

Methotrexate is widely regarded as one of the safest of all arthritis drugs, though it carries some potential downsides. Gastrointestinal symptoms such as nausea and vomiting are its most frequent side effects.

Can chloroquine cause kidney damage?

It is concluded that chloroquine administration impairs kidney function, resulting in inappropriate Na ⁺ and Cl⁻ retention. This effect is likely to be mediated via chloroquine-induced increases in plasma aldoster-one concentration and lowering of GFR.

Does hydroxychloroquine raise creatinine levels?

Results: The mean creatinine clearance decreased from 99 ml/min to 92 ml/min (p < 0.001) after the start of antimalarial drugs. Fifty-five percent of the patients with chloroquine compared to 15% of the patients with hydroxychloroquine (chi 2 = 17.8; p < 0.001) had more than 10% decrease of the creatinine clearance.

Can CKD patients take hydroxychloroquine?

Therefore, hydroxychloroquine use may be beneficial for decreasing CKD risk and can be encouraged in patients with rheumatoid arthritis. CKD is classically defined by a reduced kidney function or presence of kidney damage (27). However, serum creatinine level and eGFR were not available in the NHIRD.

Does taking hydroxychloroquine make you immunocompromised?

Please note that hydroxychloroquine (Plaquenil) does NOT suppress your immune system and does not increase any risk for a more serious illness from COVID-19.

What can I take instead of hydroxychloroquine?

Types of antimalarials

Hydroxychloroquine (Plaquenil) is the most common antimalarial for lupus. If you can't take hydroxychloroquine, your doctor may recommend chloroquine (Aralen®). These medicines can be taken as pills or liquids.

Which is safer methotrexate or hydroxychloroquine?

Safety variables at 6 month were within normal physiological ranges and did not differ in groups (p>0.05) indicating that both methotrexate and hydroxychloroquine were effective and safe to use in rheumatoid arthritis. The difference in the incidence of adverse effects, total or individual, was almost nil.

Does hydroxychloroquine affect blood pressure?

Clinically, patients with lupus treated with hydroxychloroquine present a lower prevalence of thromboembolic events [13, 14] and chronic treatment with hydroxychloroquine reduced hypertension and improved endothelium-dependent relaxation in conduit vessels from SLE mice [15].

Can you take Plaquenil for life?

Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. For this reason, you can think of anti-malarials as a sort of “lupus life insurance.”

Can hydroxychloroquine cause weight gain?

Abnormal weight gain is a side effect of long-term doxycycline and hydroxychloroquine treatment.

Can you take vitamin D with hydroxychloroquine?

Interactions between your drugs

No interactions were found between hydroxychloroquine and Vitamin D3.

Can hydroxychloroquine cause a fatty liver?

To cite this abstract in AMA style:

Association of Hydroxychloroquine Use with Development of Non-Alcoholic Fatty Liver Disease in Rheumatoid Arthritis [abstract].

Can hydroxychloroquine affect eyes?

Hydroxychloroquine (Plaquenil) and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported.

What are the benefits of taking hydroxychloroquine?

Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate.

Is hydroxychloroquine good for rheumatoid arthritis?

Hydroxychloroquine. Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Chloroquine is another antimalarial agent that is also sometimes used.

Can hydroxychloroquine cause protein in urine?

Conclusions: Hydroxychloroquines like plaquenil or geniquin may lead to a high rate of false positive with the dipstick method. A quantification assay is recommended for proteinuria measurement in patients with SLE taking hydroxychloroquines.