Does desmopressin hurt your kidneys?

The doctor may need to stop or adjust desmopressin treatment, especially in children and older adults. Children may be more sensitive to the side effects of this drug, especially water/mineral imbalance and a low level of sodium in the blood. Kidney function declines as you grow older.

Can you take desmopressin long term?

Desmopressin is the medicine commonly used to treat bedwetting. It can be used both short-term (eg, for a school trip or a sleepover) and long-term.

What are the effects of desmopressin on the body?

Desmopressin may cause serious side effects. Call your doctor at once if you have: low levels of sodium in the body--headache, confusion, hallucinations, muscle cramps, severe weakness, vomiting, loss of coordination, feeling restless or unsteady; flushing (sudden warmth, redness, or tingly feeling);

Who should not take desmopressin?

tell your doctor if you have or have ever had kidney disease or a low level of sodium in your blood. Your doctor will probably tell you not to take desmopressin. tell your doctor if you have or have ever had high blood pressure, any condition that causes you to be extremely thirsty, cystic fibrosis, or heart disease.

Can desmopressin cause kidney damage?

Renal failure could possibly exacerbate the adverse effects of desmopressin. Thus elevated plasma concentration due to reduced clearance and prolonged half-life of the drug could cause an unexpected degree of water accumulation, leading to hyponatraemia, oedema and even further deterioration of renal function.

Keeping Kidneys Safe - Know How Medicines Affect the Kidneys

What happens if you drink too much water on desmopressin?

If you take too much desmopressin or drink too much fluid while taking it, it can cause your body to retain too much water. This can result in: headaches. dizziness.

How much water should I drink on desmopressin?

20 micrograms, limit fluid intake to 500 mL from 1 hour before to 8 hours after administration.

How safe is desmopressin?

Treatment with intranasal and oral formulations of desmopressin is generally well tolerated, and side effects are usually minor. The risk of hyponatraemia, although small, can be reduced by adhering to the indications, dosing recommendations and precautions when prescribing desmopressin.

Does desmopressin cause water retention?

OVERDOSAGE. Overdosage of desmopressin leads to an increased risk of prolonged fluid retention and hyponatremia. Signs of overdosage may include nausea, headache, drowsiness, confusion, and rapid weight gain due to fluid retention.

Does desmopressin affect blood pressure?

Infrequently, desmopressin may affect your blood pressure. It may cause an increase or decrease in your blood pressure. A temporary drop in your blood pressure may result in dizziness and a fast heartbeat. Ask your doctor for more details, especially if you have heart problems or high or low blood pressure.

Is weight gain a side effect of desmopressin?

Overdose symptoms may include headache, confusion, drowsiness, rapid weight gain, or urination problems.

What drugs interact with desmopressin?

Can you drink water with desmopressin?

Limit your intake of water and other fluids while you are using desmopressin. Drinking too much water may lead to a serious, life-threatening electrolyte imbalance. Fluid restriction is especially important in children and older adults using desmopressin.

Does desmopressin cause dehydration?

Descriptions. Desmopressin is used to treat central cranial diabetes insipidus. This is a condition that causes the body to lose too much fluid and become dehydrated.

How do I wean off desmopressin?

After a few months of being dry at a particular dose, you may want to wean off the medicine. If so, try taking one less tablet each night for two weeks until you have weaned to one tablet each night. Then try taking the medicine every other day for a month and then stop the DDAVP entirely.

Does desmopressin increase sodium?

Desmopressin can be given to increase the urine concentration and reduce free-water loss, thereby limiting autocorrection of serum sodium level. It is vital that this be done carefully, and the patient must have strict fluid restrictions or have no enteral intake.

Does desmopressin cause low sodium levels?

Abstract. Desmopressin acetate (DDAVP), a medication used in the treatment of bleeding and polyuric disorders, has the potential to cause hyponatremia when free water is not appropriately restricted with its use.

Does desmopressin decreased urine output?

Conclusions: Desmopressin reduces nocturnal urine volume and nocturnal voiding frequency in male patients with nocturnal polyuria. However, increased calcium and decreased potassium excretion following desmopressin treatment deserve attention particularly when it is used on a long-term basis.

Can desmopressin cause weight loss?

Desmopressin (2-4 micrograms given intramuscularly at 8 pm) reduced nocturnal polyuria, diminished overnight weight loss, raised supine blood pressure, and reduced the postural fall, especially in the morning, when patients were often at their worst.

How often can you take desmopressin?

Adults and children 4 years of age and older—At first, 0.05 milligram (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 1.2 mg per day. Children younger than 4 years of age—Use and dose must be determined by your doctor.

How long before bed should you take desmopressin?

Desmopressin lasts eight hours so it must be taken just before your child goes to sleep and there must be no drinks until eight hours after it has been taken. It can be more effective to take Desmopressin an hour before going to sleep so that it's already working on slowing wee production as your child goes to bed.

Is desmopressin a diuretic?

Desmopressin is a man-made analogue of vasopressin which is the body's natural anti-diuretic hormone released by the pituitary. It works by increasing water permeability in renal tubular cells, which decreases urine volume and increases urine concentration.

Does desmopressin make pee?

This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration. Desmopressin is also used to control nighttime bedwetting in children.

Can you take ibuprofen with desmopressin acetate?

ibuprofen desmopressin

Using desmopressin together with ibuprofen may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In severe cases, hyponatremia can lead to seizures, coma, and even death.

Can I take Tylenol with desmopressin?

Interactions between your drugs

No interactions were found between desmopressin and Tylenol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.