Does Benadryl interact with any other medications?

A total of 413 drugs are known to interact with Benadryl (diphenhydramine), categorized as 12 major, 399 moderate, and 2 minor interactions.
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What medications Cannot be taken with Benadryl?

Benadryl may interact with other types of medication, which can heighten the side effects.
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Examples of medications that may interact with Benadryl include:
  • antidepressants.
  • stomach ulcer medicine.
  • cough and cold medicine.
  • other antihistamines.
  • diazepam (Valium)
  • sedatives.
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Does Benadryl interact with blood pressure meds?

Answer. According to the drug interaction checker, Benadryl can increase the effects of diltiazem, which could cause your blood pressure to drop too much. It advises close monitoring of blood pressure if they are taken together. Ideally, I would say to check with your doctor before taking the Benadryl.
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Is Benadryl safe to take with other drugs?

Benadryl has the potential to interact with a variety of medications. It may interact with medications that are used to treat dementia and Alzheimer's disease, such as Aricept, Razadyne and Exelon. These medications and Benadryl can lessen the effects of each other.
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When should I not take Benadryl?

Do not use diphenhydramine for longer than 2 weeks to treat sleep problems, or longer than 7 days to treat cold or allergy symptoms. This medicine can affect the results of allergy skin tests. Tell any doctor who treats you that you are using diphenhydramine.
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Why doctors are advising against Benadryl



Why is Benadryl not recommended for over 65?

Benadryl (diphenhydramine) and hydroxyzine are common examples of anticholinergic medications that are not cleared as well from the system in older people. This can lead to confusion, dry mouth, and constipation.
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What does Benadryl do to your heart?

Benadryl can increase your heart rate and may cause more serious heart-related side effects, such as heart rhythm problems. If you already have heart disease, taking Benadryl can make your condition worse. Talk with your doctor about whether it's safe for you to take Benadryl.
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Does Benadryl raise blood pressure?

Benadryl may cause a drop in blood pressure which may cause symptoms such as dizziness and increase your risk of falls.
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Can Tylenol and Benadryl be taken together?

Interactions between your drugs

No interactions were found between Benadryl and Tylenol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
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Which patient should not use Benadryl diphenhydramine )?

You should not use diphenhydramine if you are allergic to it. Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: Ask a doctor before using this medicine if you are pregnant or breastfeeding. Diphenhydramine may slow breast milk production.
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Does Benadryl cause heart palpitations?

Many medicines, including diet pills, antihistamines, decongestants, and some herbal products, can cause heart palpitations.
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What are the negative effects of Benadryl?

Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
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Can I take Benadryl if I'm taking lisinopril?

diphenhydrAMINE lisinopril

Lisinopril and diphenhydrAMINE may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.
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Who shouldn't take antihistamines?

Who shouldn't take antihistamines?
  • Glaucoma.
  • Trouble urinating (from an enlarged prostate gland)
  • Breathing problems, such as asthma, emphysema, or chronic bronchitis.
  • Thyroid disease.
  • Heart disease.
  • High blood pressure.
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Can I take ibuprofen with Benadryl?

Interactions between your drugs

No interactions were found between Benadryl and ibuprofen. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
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What 2 allergy meds can be taken together?

Well, you could. You can mix and match, especially with antihistamines and nasal sprays. Those are probably my two favorites to use in combination amongst the antihistamines. I probably wouldn't do Zyrtec and Allegra and Claritin.
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Can you take Advil or Tylenol with Benadryl?

Interactions between your drugs

No interactions were found between Advil and Benadryl. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
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How long does Benadryl take to work?

How long does it take diphenhydramine (Benadryl) to start working? Diphenhydramine (Benadryl) starts to work pretty quickly. You can expect to it to kick in within about 15 to 30 minutes. Its full effects can be felt around 2 hours after your dose.
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Can I take Benadryl for Covid?

A pair of over-the-counter compounds has been found in preliminary tests to inhibit the virus that causes COVID-19, University of Florida Health researchers have found. The combination includes diphenhydramine, an antihistamine used for allergy symptoms.
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How do you flush Benadryl out of your system?

Hydration: The more water you drink, the quicker diphenhydramine is flushed from the system. Metabolism: Everyone's body metabolizes or breaks down drugs and similar substances at a different rate. The faster your drug metabolism is, the less time diphenhydramine stays in your system.
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Is it OK to take Benadryl every night?

Is it safe to take diphenhydramine every night? You should not take diphenhydramine every night. While it may be helpful during limited periods of insomnia, your body will build up a tolerance for the medication over time, and it will no longer have the desired effect.
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Is Benadryl hard on your liver?

Despite widespread use over many decades, diphenhydramine has not been linked to liver test abnormalities or to clinically apparent liver injury. The reason for its safety may relate its short half-life and limited duration of use. Likelihood score: E (unlikely to be a cause of clinically apparent liver injury).
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Is Benadryl good for anxiety?

Benadryl is not intended for long-term use, and while it may reduce anxiety symptoms in some individuals, the risks outweigh the benefits. Although it might provide temporary sleepiness, these effects don't last with regular use.
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Can Benadryl hurt your kidneys?

Acute kidney injury (AKI) can be caused by a commonly used over-the-counter and prescription medication, diphenhydramine (Benadryl, McNeil). We do not usually think of this drug as a major source of renal impairment, but it can cause problems in some predisposed patients, including elderly populations.
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Can Benadryl cause anxiety?

It's also possible that after taking Benadryl some people can feel: restless. excitable. anxious.
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