Can metformin give you depression?

One underdiagnosed side effect of metformin is the increased risk of cobalamin (vitamin B12) deficiency due to diminished uptake of cobalamin by the terminal ileum, and cobalamin deficiency was associated with an increased risk of depression and decreased cognitive performance.

Can metformin cause anxiety and depression?

The women on metformin had 70% lower odds of having major depression (PHQ-9≥10) (OR=0.302, P=0.045); however, no significant effect of metformin on anxiety (GAD-7≥10) was found.

Can metformin affect your mood?

With the highest recorded proportion in the study, with the exception of menstrual irregularities, mood swings were indicated by 92% of the participants. However, after treatment with metformin, 64% reported the problem.

Can diabetes medicine cause depression?

But “there is long-term stress and strain associated with diabetes management such as blood sugar control and treatment for complications, and this can lead to decreased quality of life and increased probability of depression,” he says.

Does metformin cause stress?

Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation. J Affect Disord. 2020 Jan 1;260:302-313.

Why are Diabetes and Depression Linked? | Sherita Golden, M.D., M.H.S.

What is the most common side effect of metformin?

Nausea, vomiting, and diarrhea are some of the most common side effects people have when they first start taking metformin. These problems usually go away over time.

Can diabetes cause anxiety and depression?

Changes in blood sugar can cause rapid changes in mood and other mental symptoms such as fatigue, trouble thinking clearly, and anxiety. Having diabetes can cause a condition called diabetes distress which shares some traits of stress, depression and anxiety.

What is the best antidepressant for diabetics?

Bupropion, a norepinephrine/dopamine reuptake inhibitor, is as effective for in the treatment of depression as the SSRIs,⁶² and has shown favorable effects on weight in patients with obesity and depressive symptoms⁶³ and on glycemic control in patients with diabetes.

Why do diabetics get so angry?

What's sometimes called "diabetic rage" can be dangerous, because it may involve behaviors you're not consciously aware of. When your blood sugar fluctuates, spikes, or drops, it can produce feelings of anger, anxiety, or depression. You may feel like your emotions are out of your control.

Can diabetes affect your emotions?

Feeling a range of highs and lows is not uncommon if you have diabetes. Your blood sugar impacts how you feel and can contribute to mood swings. Poor management of blood glucose can lead to negative moods and a lower quality of life .

Does metformin help with anxiety and depression?

The study suggested that metformin increased serotonin levels in the brain, a hormone associated with wellbeing and happiness. This led to reduced anxiety-like behaviours which the researchers referred to as “one of the most visible and early symptoms of depression”.

How does metformin make you feel?

Metformin does cause side effects in some people, but many of these are mild, and are associated with taking the medicine for the first time. Nausea and gastric distress such as stomach pain, gas, bloating, and diarrhea are somewhat common among people starting up on metformin.

Can you take antidepressants with metformin?

No interactions were found between metformin and Zoloft.

Does metformin give anxiety?

The team — led by Bruno Guiard, Ph. D., an associate professor of neuroscience and pharmacology at the University of Toulouse — found that metformin reduced anxiety-like behaviors in the mice. This, the researchers observed, was because the diabetes drug boosted levels of serotonin in the brain.

Is metformin an antidepressant?

In addition, metformin is a first-line drug for Type 2 diabetes in past 60 years for its safety [8,53]. Therefore, metformin is a promising antidepressant to be used in the clinic for patients with depression.

How does depression affect diabetes?

Depression can lead to poor lifestyle decisions, such as unhealthy eating, less exercise, smoking and weight gain — all of which are risk factors for diabetes. Depression affects your ability to perform tasks, communicate and think clearly. This can interfere with your ability to successfully manage diabetes.

Can diabetes cause mental confusion?

When diabetes is poorly controlled, it can lead to delirium. This acute state of severe confusion and behavior change is difficult to treat and is associated with higher risk for long-term cognitive impairment and even death.

Is diabetes a disability?

Specifically, federal laws, such as the Americans with Disabilities Act and the Rehabilitation Act, protect qualified individuals with a disability. Since 2009, amendments and regulations for these laws make clear that diabetes is a disability since it substantially limits the function of the endocrine system.

Can you take antidepressants if you have diabetes?

Yet, there are positive reports concerning the SSRIs (paroxetine, citalopram, sertraline), as well as nefazodone, that focus on serotonin selectivity. Conclusions: In comorbid diabetes mellitus and depression, most evidence supports the use of fluoxetine in control of glucose handling.

Can diabetics take anxiety medication?

There are several different types of medications you can take to manage anxiety, such as antidepressants and anti-anxiety drugs. Although they're generally compatible with diabetes medications, you should always tell your doctor what you're taking, to be safe.

Is there a link between antidepressants and diabetes?

Several antidepressants are associated with significant weight gain, which in turn increases insulin resistance and the risk of diabetes (2,33). However, several studies still observed an increased risk of diabetes after adjustment for changes in body weight, implying that other mechanisms are involved.

Which mental illness is definitely associated with diabetes?

Some of the psychiatric disorders of particular relevance with regard to diabetes include delirium, substance use disorders, depression, anxiety, psychotic illness like schizophrenia, eating disorders. The subsequent section presents an overview of these psychiatric conditions in the context of diabetes.

How Type 2 diabetes increases the risk of depression?

Some researchers have argued that diabetes precedes depression and increases the risk of developing depression due to the psychological trauma following diagnoses of diabetes and its burdens such as hyperglycemia leading to altered glucose transport or treatment of the disease itself or both combined as they pose ...

What are the long term effects of taking metformin?

Can metformin can cause nerve damage? Along with increasing your risk for anemia, low vitamin B12 levels may also contribute to nerve damage (or neuropathy), which can cause chronic nerve pain.

Does metformin cause tiredness?

Taking metformin can cause vitamin B12 deficiency if you take it for a long time. This can make you feel very tired, breathless and faint, so your doctor may check the vitamin B12 level in your blood.