Can clopidogrel cause stomach problems?

Other adverse GI effects reported by patients taking clopidogrel include GI discomfort, diarrhea, constipation, dyspepsia, nausea and abdominal pain although the incidence is not known [3, 4, 7, 12, 16, 17].

Does clopidogrel cause stomach issues?

Clopidogrel use is associated with an increased risk of adverse GI events such as gastritis, ulcer and bleeding, yet the risk is only modest with an odds ratio of less than 2.0.

What are the most common side effects of clopidogrel?

Does clopidogrel cause indigestion?

Clopidogrel can cause stomach upset or heartburn. If this happens, always take your clopidogrel after food or with a glass of milk. If you develop heartburn, indigestion or your bowel motions become black, contact your doctor for further advice.

What is the most serious adverse effect of clopidogrel?

Clopidogrel may increase the risk of serious bleeding during a surgery, other medical procedures (eg, coronary stent procedure), or some kinds of dental work. You may need to stop using this medicine at least 5 days before a surgery, medical procedure, or dental work.

Clopidogrel - How to take | Side Effects | Things to be aware

Do the side effects of clopidogrel go away?

Some side effects of clopidogrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Is there an alternative to clopidogrel?

Ticagrelor and prasugrel are antiplatelet drugs that are alternatives to clopidogrel in acute coronary syndrome. Their advantages include reduced rates of ischaemia and stent thrombosis.

What is the best antacid to take with clopidogrel?

The FDA advises that if you are experiencing heartburn or acid reflux while taking Plavix, you should try using antacids ( Maalox, Mylanta, Rolaids, Tums and generics) and most H2 blockers such as famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac), but not cimetidine (Tagamet, Tagamet HB, and generics).

Can Plavix make acid reflux worse?

Because Plavix can upset the stomach, it is often prescribed with stomach acid-blocking drugs. The FDA says patients who need to reduce their acid should take drugs from the H-2 blocker family, which include Johnson & Johnson's Mylanta and Boehringer Ingelheim's Zantac.

What foods should I avoid while taking clopidogrel?

Is there any food or drink I need to avoid? Do not drink grapefruit juice while taking clopidogrel. Grapefruit juice decreases the effects of your medicine, so that it may not work as well to prevent clots.

What should I monitor with clopidogrel?

HPR while on this drug is associated with major adverse cardiovascular events. The best assays to monitor clopidogrel therapy include VerifyNow and Multiplate ADP test.

Does clopidogrel cause constipation?

Other adverse GI effects reported by patients taking clopidogrel include GI discomfort, diarrhea, constipation, dyspepsia, nausea and abdominal pain although the incidence is not known [3, 4, 7, 12, 16, 17].

When is the best time to take clopidogrel?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.

Is clopidogrel easier on the stomach than aspirin?

Abstract. Background: Clopidogrel causes significantly less symptomatic peptic ulcer disease and gastrointestinal bleeding than low-dose aspirin in average-risk patients.

Can clopidogrel cause gastrointestinal bleeding?

Conclusions: Clopidogrel is associated with a high incidence of upper gastrointestinal bleeding in high-risk patients. A previous history of gastrointestinal bleeding appears to be a predictor of adverse gastrointestinal events.

Does clopidogrel cause peptic ulcer?

Most peptic ulcers in clopidogrel users are located in the stomach. The frequencies of hemorrhagic spots and peptic ulcers in symptomatic clopidogrel users are higher than those in symptomatic aspirin users. The patients who received clopidogrel had more hemorrhagic spots, peptic ulcers and higher Lanza score.

Can blood thinners affect your stomach?

Gastrointestinal bleeding is a common side effect for many blood-thinning medications. But new Mayo Clinic research finds that risk is amplified when patients receive more than one blood thinner – especially if they're 75 or older.

Do blood thinners cause indigestion?

Since blood thinners like Plavix can cause stomach problems including heartburn and ulcers, doctors also used to regularly give patients heartburn drugs.

Can I take omeprazole with clopidogrel?

Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable.

What can I take for heartburn while on blood thinners?

Antacids, like Maalox, Mylanta, or Tums help neutralize stomach acid. H2 blockers, like Pepcid AC, Tagamet, and Zantac, reduce stomach acid production.

Can you take omeprazole while on blood thinners?

Taking omeprazole at the same time as blood thinners could reduce the blood thinners' effectiveness (FDA, 2018). Studies have found that long-term use of the drug can put patients at a higher risk of developing kidney disease, bone fractures, and irritable bowel disease (Kinoshita, 2018).

How long does it take for stomach acid to return to normal after stopping PPI?

Serum markers suggest that acid secretion one week following cessation of PPI treatment can be significantly increased above pre-treatment levels. This should return to normal within two weeks.

Is long term use of clopidogrel safe?

Safety Announcement

[ 11-06-2015 ] A U.S. Food and Drug Administration (FDA) review has determined that long-term use of the blood-thinning drug Plavix (clopidogrel) does not increase or decrease overall risk of death in patients with, or at risk for, heart disease.

Can I drink coffee with clopidogrel?

These medications are used to slow blood clotting and include aspirin, clopidogrel (Plavix), ibuprofen (Advil, Motrin, and others), naproxen (Anaprox, Naprosyn, and others), enoxaparin (Lovenox), and more. Health experts advise caution when combining them with coffee, which can also slow blood clotting.

Does clopidogrel make you tired?

Clopidogrel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: excessive tiredness. headache.