What is the most common initial site of Paget's disease?

Paget's disease usually begins in the cancellous bone of an epiphysis or metaphysis. A diaphysis

diaphysis

Diaphysis - Refers to the main part of the shaft of a long bone.

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Anatomy, Bone Markings - StatPearls - NCBI Bookshelf

is the first site involved in some instances, and the anterior subperiosteal area of the proximal half of the tibia in a very small number of cases.

Where is Pagets disease most common?

The pelvis, skull, spine and legs are most commonly affected. The risk of Paget's disease of bone increases with age and if family members have the disorder. However, for reasons unknown to doctors, the disease has become less common over the past several years and is less severe when it does develop.

What are the four most common areas affected by Paget's disease?

The new bone may occur in one or more regions of the body and is structurally abnormal, dense and fragile. This abnormal development may cause bone pain, arthritis, deformities and fractures. The bones most frequently affected are in the spine, skull, pelvis and lower legs.

What initial symptom of Paget's disease is?

Symptoms of Paget's disease of bone

Commonly affected areas include the pelvis, spine and skull. Symptoms can include: constant, dull bone pain. joint pain, stiffness and swelling. a shooting pain that travels along or across the body, numbness and tingling, or loss of movement in part of the body.

What of the following is the most common appearance of Paget's disease?

Paget's disease can affect any bone in the skeleton. It appears most often in the spine, pelvis, long bones of the limbs, and skull. It can be present in just one bone or in several bones.

Paget's Disease of the Bone - New Endocrine Society Clinical Practice Guideline

What is Paget's disease of the skin?

Background: Paget's disease is an uncommon epidermal cancer, affecting all skin regions wherever apocrine glands are present. It is divided into extramammary (EMPD) and mammary Paget's disease (MPD). It can be confined to the epithelium or may be associated with an underlying adenocarcinoma.

What are the symptoms of Paget's disease of the breast?

What are the stages of Paget disease?

Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. In an individual patient, different skeletal lesions may progress at different rates. Thus, at any one time, multiple stages of the disease may be demonstrated in different skeletal regions.

What is the pathology of Paget's disease?

Pathology. Paget's disease is a focal disorder of skeletal remodeling in which the primary cellular abnormality is an increase in osteoclastic resorption of bone (Fig. 1). Increased bone resorption leads to a compensatory increase in bone formation.

How quickly does Paget's disease progress?

Mammary Paget's disease is associated with carcinoma of the underlying lactipherous ducts. The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue.

How is Paget's disease diagnosed?

X-ray and bone scan

An X-ray can show whether your bones have become enlarged as a result of Paget's disease of bone. Sometimes a bone scan called scintigraphy may also be carried out to check how much of your body is affected by the condition.

What causes Hollowbones?

The usual cause is deficiency of vitamin D, which is required for utilization of calcium and phosphorus by the body. In osteitis fibrosa cystica, bone is replaced by fibrous tissue because of abnormal calcium metabolism. The condition usually is due to overactivity of the parathyroid glands.

Why is it called Paget's disease?

Men are more commonly affected than women (3:2). The disease is named after English surgeon Sir James Paget, who described it in 1877.

What is the most common bone site of osteomyelitis?

Among children and teens, the long bones of the legs and arms are most frequently affected. In adults, osteomyelitis most often affects the vertebrae of the spine and/or the hips. However, extremities are frequently involved due to skin wounds, trauma and surgeries.

What is Paget's disease of the spine?

Paget's disease occurs when your bone cells don't function properly, resulting in deformed, enlarged, and fragile bones. The bones of your spine (vertebrae) are susceptible to this condition.

What is Paget's disease of the hip?

Paget's disease of bone is a chronic bone disorder. Normally, there is a process in which your bones break down and then regrow. In Paget's disease, this process is abnormal. There is excessive breakdown and regrowth of bone. Because the bones regrow too quickly, they are bigger and softer than normal.

What is the differential diagnosis of Paget's disease?

The differential diagnosis of Paget disease includes osteomalacia, which may be part of the spectrum of osseous abnormalities accompanying chronic renal insufficiency. Patients with mild osteomalacia may present with nonspecific bone pain and tenderness.

Which one of the following histological features is found in Paget's disease?

The major histologic feature of Paget disease is abnormal bony architecture.

Which of the following characteristics best describes Paget's disease quizlet?

Which of the following best describes Paget's disease? It is an excessive rate of bone deposition and resorption, characterized by a high ratio of immature woven bone to mature compact bone; osteoblasts outpace osteoclasts and bones thicken in an irregular manner.

What is the most common age for females to be diagnosed with Paget's disease?

Paget's disease of the breast occurs most often after age 50. Most people with this diagnosis also have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer. Only rarely is Paget's disease of the breast confined to the nipple itself.

What is the difference between Paget's disease and osteoporosis?

Osteoporosis affects many bones. With Paget's bone disease, there is an imbalance in the daily process of bone breakdown and buildup. The breakdown process runs amok, and the rebuilding process is at a loss to catch up.

Where does IBC rash start?

Symptoms of IBC usually take just 3-6 months to develop. Your symptoms may include: A red or purple color or a rash spread over one-third of the breast. Pitting, thickening, or dimpling of skin on the breast, so that it looks like an orange peel, a condition called peau d'orange.

Does Paget's disease of the breast come and go?

In most cases, Paget's disease affects one breast, and the symptoms may come and go. This means symptoms may cycle through, appearing to improve and then worsen again. The symptoms may look similar to eczema or other such skin conditions.

How can you tell the difference between Paget's disease and eczema?

Paget's disease may affect your nipple, while eczema rarely affects your nipple. Paget's disease also typically only affects one breast, while eczema affects both breasts and other parts of your chest. Paget's disease won't respond to the same treatments as eczema.