Why is propofol so good?

Propofol is a strong anesthetic that's used for surgery, some medical exams, and for sedation for people on ventilators -- never as a sleep aid. It's given by IV and should only be administered by a medical professional trained in its use. It takes effect in a matter of seconds.
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Why do you feel so good after propofol?

Since propofol stimulates the dopamine expression in the central reward system, however, it bears a potential risk of addiction and induces addiction-like behavior in animal models. Additionally, a subgroup of healthy volunteers reported having experienced euphoric moods after propofol administration.
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Does propofol feel good?

Patients sedated with propofol rarely complain of feeling "drugged" and more often remark that they feel as if they had a great nap. While fentanyl and other opioid-type drugs may cause nausea, particularly at higher doses, this is rare with propofol.
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Why is propofol so popular?

Because of its rapid induction and recovery time, propofol is also widely used for sedation of infants and children undergoing MRI. It is also often used in combination with ketamine with minimal side effects.
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What are propofol advantages?

Proposed benefits of propofol sedation include rapid onset of action, improved patient comfort and rapid clearance, as well as prompt recovery and discharge from the endoscopy unit.
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The power of propofol



How does propofol work so fast?

It's given by IV and should only be administered by a medical professional trained in its use. It takes effect in a matter of seconds. "It is very fast-acting and works by slowing brain wave activities, says John F. Dombrowski, MD, an anesthesiologist/pain specialist at the Washington Pain Center in Washington, D.C.
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Can someone become addicted to propofol?

Because propofol has intrinsic limitations, including a lack of street availability and the requirement for intravenous administration, it is generally believed not to be of interest to drug abusers. However, healthcare providers in Western society can easily become addicted to propofol because of easy access.
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Why is propofol given slowly?

The drug should be administered slowly, intravenously, to minimize the negative cardiac and respiratory effects seen after rapid bolus administration. The currently available formulations do not contain preservatives, and sterile technique should be strictly followed during its use.
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Is propofol a narcotic?

Propofol is not scheduled under the Controlled Substances Act (CSA).
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How long does propofol keep you asleep?

Propofol causes severe drowsiness and dizziness, which may last for several hours. You will need someone to drive you home after your surgery or procedure. Do not drive yourself or do anything that requires you to be awake and alert for at least 24 hours after you have been treated with propofol.
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Can you talk on propofol?

Patients do not talk during the anaesthetic while they are unconscious, but it is not uncommon for them to do so during emergence from anaesthesia.
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Is propofol a twilight anesthesia?

Common Drugs Found in Twilight Anesthesia

Valium. Ketamine. Midazolam. Propofol.
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Why do you wake up crying after anesthesia?

“There is a medication called Sevoflurane, which is a gas that we use commonly to keep patients asleep there's some increased incidence of crying when that medication is used,” said Heitz. But he suspects many factors could be involved; the stress of surgery, combined with medications and feeling slightly disoriented.
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How fast do you wake up from propofol?

Propofol has a rapid distribution half-life which leads to rapid awakening from a bolus dose of approximately 8–10 minutes.
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Does propofol make you feel drunk?

When people inject it in smaller amounts, the effects of Propofol are similar to the effects of alcohol. People will often feel giddy, lose inhibitions, feel spacey, and mellow.
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What drug puts you to sleep instantly?

About zolpidem

Zolpidem is a sleeping pill. It's used to treat insomnia (when you might have trouble getting to sleep and staying asleep). It helps you fall asleep more quickly and makes you less likely to wake up during the night.
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What was the drug given to Michael Jackson to sleep?

Prosecutors built a strong case that the 50-year-old “king of pop” died after Dr. Conrad Murray had given Jackson a large dose of propofol (pronounced PRO-poe-fall), a powerful anesthetic, to help him sleep and then left him unattended.
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Can I take Xanax after propofol?

Interactions between your drugs

Using propofol together with ALPRAZolam may have increased effects on breathing, heart rate, blood pressure, and sedation. You will be monitored closely by your surgical team during anesthesia, and the doses of each medication adjusted accordingly.
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Why is propofol in a glass bottle?

Propofol has been reported to have high stability in glass and relatively high stability up to 24 hours in polyvinyl chloride-based medical plastics.
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Can you feel pain with propofol?

What side effects does propofol have? It can cause a decrease in blood pressure, it can depress or even stop breathing, and it can cause pain on injection.
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What are the disadvantages of propofol?

Propofol has some disadvantages, however, including pain on injection, involuntary movements, transient apnea, and hypotension after induction of anesthesia.
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How does propofol affect the brain?

In the unconscious state, propofol sharply reduces the regional glucose metabolism rate (rGMR) and regional cerebral blood flow (rCBF) in all brain regions, particularly in the thalamus.
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Is propofol a sedative or paralytic?

Propofol is commonly administrated for sedation in the ICU. It acts on the gamma-aminobutyric acid receptor at a different binding site than benzodiazepines. It is an intravenous general anesthetic agent with sedative, hypnotic, amnestic, and anticonvulsant properties.
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Does anesthesia make you tell the truth?

Anesthesia won't make you confess your deepest secrets

Rest assured, even if you do say something you wouldn't normally say while you are under sedation, Dr. Meisinger says, “it's always kept within the operating room. We know the patient is under extra medications and it's not a concern to us at all.”
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