Which is safer aspirin or clopidogrel?

Aspirin combined with the antiplatelet drug

antiplatelet drug

Antiplatelets can be classified based on the mechanism of action as follows[2][3]: Platelet aggregation inhibitors such as; Aspirin and related cyclooxygenase inhibitors. Oral thienopyridines such as clopidogrel, ticagrelor, ticlopidine, and prasugrel.

https://www.ncbi.nlm.nih.gov › books › NBK537062

Antiplatelet Medications - StatPearls - NCBI Bookshelf

clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes

lacunar strokes

Lacunar syndromes are clinical manifestations of lacunar infarctions, which are defined as small subcortical lesions less than 15 millimeters in diameter that are caused by occlusion of a penetrating artery from a large cerebral artery, most commonly from the Circle of Willis.

https://www.ncbi.nlm.nih.gov › books › NBK534206

Lacunar Syndromes - StatPearls - NCBI Bookshelf

, and the combination carries a greater risk of gastrointestinal bleeding, according to results of a trial funded by the National Institutes of Health.

Which one is better clopidogrel or aspirin?

Clopidogrel is another guideline‐recommended antiplatelet agent²¹ and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).

Why is clopidogrel preferred to aspirin?

Several clinical trials reported that clopidogrel was superior to aspirin in secondary stroke prevention by reducing the risk of major adverse cardiovascular events (MACE).

Is there an alternative to aspirin and clopidogrel?

Besides oral anticoagulants, such as warfarin and the more recent dabigatran[9], and niche agents, such as cilostazol and ticlopidine[10,11], the most promising alternatives to clopidogrel in those with background aspirin therapy are prasugrel and ticagrelor.

How long should you stay on clopidogrel?

The standard recommendation is typically at least 12 months of Plavix. But the study found that six months of treatment was enough to prevent rare but deadly complications, says researcher Marco Valgimigli, MD, of the University Hospital of Ferrara, in Italy.

Asprin vs Plavix? Which is better?

Can you take clopidogrel for life?

Clopidogrel is generally safe to take for a long time. In fact, it works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to help protect your stomach while you're taking clopidogrel.

Is there an alternative to clopidogrel?

Ticagrelor and prasugrel are antiplatelet drugs that are alternatives to clopidogrel in acute coronary syndrome. Their advantages include reduced rates of ischaemia and stent thrombosis.

Can clopidogrel damage kidneys?

Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome.

What's the next best thing to aspirin?

Tylenol, the widely used alternative to aspirin, is an analgesic, or pain reliever, and fever-reducing drug. The drug is often used by people who are allergic to aspirin or who suffer medical problems, notably stomach ulcers or such bleeding conditions as hemophilia, that make aspirin use unsuitable.

What can I take instead of aspirin for heart?

If aspirin is safe for you but it irritates your stomach, talk to your doctor about adding a stomach-protecting drug such as lansoprazole (Prevacid, Prevacid 24HR, and generic) or omeprazole (Prilosec, Prilosec OTC, and generic).

What is the safest antiplatelet drug?

Clopidogrel monotherapy showed the most favourable benefit-harm profile (79% cumulative rank probability best and 77% cumulative rank probability safest). In conclusion, Clopidogrel should be the indicated antiplatelet agent in PAD patients.

How much stronger is clopidogrel than aspirin?

In the present study, the MACE rates for aspirin and clopidogrel are 30.3% and 45.4% respectively. They are substantially higher than those reported in previous studies showing the MACE rates around 10% for both antiplatelet agents [20, 21].

Can you still have a stroke when taking clopidogrel?

The anti-blood clot regimen that adds the drug clopidogrel (Plavix) to aspirin treatment is unlikely to prevent recurrent strokes and may increase the risk of bleeding and death in patients with subcortical stroke according to late-breaking research presented at the American Stroke Association's International Stroke ...

What are the side effects of clopidogrel 75 mg?

When is the best time to take clopidogrel?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.

Does clopidogrel increase bleeding risk?

In conclusion, we found that among patients receiving DES, clopidogrel use was associated with an increased risk of major bleeding over a broad range of time intervals out to 18 months. In contrast, clopidogrel use was associated with decreased risk of MI in all time intervals and death in the 7- to 12-month interval.

What blood thinner is safer than aspirin?

Summary: The blood thinner rivaroxaban is as safe as aspirin, and more effective at preventing recurrence of life-threatening blood clots in the legs and lungs, according to a new study.

How can I thin my blood without aspirin?

Is there an alternative to taking aspirin for blood-thinning?

What's the alternative to aspirin? People who are advised to take an aspirin by their doctor but can't, most commonly because they are sensitive asthmatics, can sometimes take the drug clopidogrel. This drug inhibits the blood platelets but doesn't affect cyclooxygenase.

Which blood thinner is easiest on your kidneys?

DOACs are a novel type of blood thinner that require less monitoring and are easier to take than VKAs like warfarin. They've been shown to work as well – if not better – at preventing strokes with fewer side effects. DOACs also appear safer than VKAs in patients with early stage kidney disease.

What should you not take with clopidogrel?

Does clopidogrel affect blood pressure?

You likely won't have blood pressure changes while you're taking Plavix. However, sudden drops in blood pressure may be a symptom of serious internal bleeding, which is a possible side effect of Plavix.

Can clopidogrel cause brain bleeding?

Background-—Although clopidogrel reduces the incidence of atherothrombotic events, its use is associated with an increased risk of major bleeding. Cerebral microbleeds (CMBs) are indicative of subclinical microangiopathy in the brain and may prelude symptomatic intracerebral hemorrhage.

What medication is better than Plavix?

Brilinta has been marketed and studied as a more effective drug than Plavix. It has been shown to be a better drug for reducing rates of cardiovascular death and preventing heart attack or stroke.

Can clopidogrel cause anxiety?

headache, fever, weakness, feeling tired; little or no urination; a seizure; low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or.