When will Trikafta be generic?

Gador are currently developing a generic elexacaftor, enabling them to produce a generic Trikafta®/Kaftrio®. They forecast that this will be ready to launch in Q3 2021.
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Is there a generic for Trikafta?

Generic Name & Formulations:

Elexacaftor, tezacaftor, ivacaftor; 50mg/25mg/37.5mg with ivacaftor 75mg; 100mg/50mg/75mg with ivacaftor 150mg; tabs.
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How much does Trikafta cost for a year?

Trikafta will cost $311,503 annually, or $23,896 per 28-day pack, according to the Securities and Exchange Commission. Analysts expect the drug to make $630 million in 2020, Reuters reports.
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When does Trikafta leave patent?

Although the patents for Kalydeco, Orkambi, and Symdeko will expire near the end of the decade, Vertex's patents for Trikafta won't expire until 2037.
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How much does it cost to make Trikafta?

Trikafta – tezacaftor/ivacaftor/elexacaftor

As such, estimated total API cost for one year of treatment was $4785. After accounting for production costs, the final estimated annual cost of treatment was $5676 (Figure 1c).
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ResearchCon 2020 | After Trikafta: The Future of Modulators and Potential Effects on Treating CF



Will Trikafta increase life expectancy?

Use of Trikafta could mean an increase in the life expectancy of cystic fibrosis patients, and for young children who begin the treatment early, “They might never have to experience the symptoms of cystic fibrosis in the same way prior to Trikafta,” Quinn said.
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How much is Trikafta in Canada?

Trikafta costs approximately $300,000 per patient per year. Health Canada approved Trikafta in June. The approval process included a review by the Canadian Agency for Drugs and Technologies in Health, and coverage in Nova Scotia will be based on the agency's recommendations.
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How many CF patients are eligible for Trikafta?

Key opinion leaders interviewed by GlobalData asserted that for patients born in the past decade, the median survival is more than 50 years of age. At present, Trikafta/Kaftrio is the world's first triple-combination CF therapy, with around 90% of the CF population likely to be eligible for it.
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Is Kaftrio the same as Trikafta?

Trikafta is the US name for Kaftrio, whereas the drug has the brand name Kaftrio in Europe. The two names refer to the same drug.
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What is the life expectancy for cystic fibrosis?

Today, the average life span for people with CF who live to adulthood is about 44 years. Death is most often caused by lung complications.
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Is Trikafta a cure for cystic fibrosis?

Summary. Trikafta® is a highly effective therapy for the underlying cause of cystic fibrosis. It is approved for use in people with CF ages 6 and older who have at least one copy of the F508del mutation or certain mutations in the CFTR gene that are responsive based on lab data. It is not a cure for CF.
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What countries have access to Trikafta?

Trikafta has received public reimbursement in numerous countries including: the United States, United Kingdom, Ireland, Austria, Denmark, Germany, and Slovenia.
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How much is Kaftrio?

A new drug Kaftrio, now available on the NHS, has made a huge difference to patients like Luke Copsey who has cystic fibrosis. Its list price is a mind-blowing £100,000 per year, although the health service has negotiated an undisclosed discount with the manufacturer. For Luke, the tablets are priceless.
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Is Trikafta better than Symdeko?

The panel voted 14-0 that the clinical evidence was adequate to demonstrate greater net health benefit for Trikafta compared with both best supportive care and Symdeko for patients homozygous for the F508del mutation.
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What is the latest treatment for cystic fibrosis?

The FDA has approved these medications for treating CF in people with one or more mutations in the CFTR gene: The newest combination medication containing elexacaftor, ivacaftor and tezacaftor (Trikafta) is approved for people age 12 years and older and considered a breakthrough by many experts.
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What is the best drug for cystic fibrosis?

Trikafta is the first approved treatment that is effective for cystic fibrosis patients 12 years and older with at least one F508del mutation, which affects 90% of the population with cystic fibrosis or roughly 27,000 people in the United States.
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Does Trikafta affect the liver?

What are the possible side effects of TRIKAFTA? TRIKAFTA can cause serious side effects, including: Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation.
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Is Kaftrio available on NHS?

June Raine, MHRA chief executive, said: “It's very good news that after a rigorous review, we have approved Kaftrio for children aged six to 11, enabling the NHS to bring this life-saving treatment to more children suffering from cystic fibrosis.
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Does Trikafta improve lung function?

The triple-combination therapy Trikafta significantly improved lung function and life quality in a global Phase 3 trial that enrolled people with cystic fibrosis (CF) caused by one F508del mutation, and one gating mutation or one residual function mutation, in the CFTR gene.
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Does Trikafta cause weight gain?

Along with all the positive lung-related improvements, I also began to gain weight. My CF care team had said from the beginning that weight gain was experienced by people on Trikafta. I have been about the same weight within a few pounds for the past seven-to-eight years.
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Who is not eligible for Trikafta?

Am I Eligible for TRIKAFTA®? TRIKAFTA is for people age 6 years and older with at least one F508del mutation or at least one other mutation in the cystic fibrosis (CF) gene that is responsive to TRIKAFTA. Enter your mutations to see if at least one of them is eligible.
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Is Trikafta on PBS?

The Hon Greg Hunt MP

From April 1, Trikafta® (elexacaftor/tezacaftor/ivacaftor and ivacaftor) will be available on the PBS for the first time for Australians with cystic fibrosis aged 12 years and older, who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
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Does OHIP cover Trikafta?

OHIP+ excludes anyone with private insurance. This is a major barrier to access for those under 25 years of age who have private insurance, especially for those whose private insurance does not cover Trikafta.
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Which provinces cover Trikafta?

TORONTO, September 24, 2021 – Cystic Fibrosis Canada welcomes the news that Trikafta, the life-changing drug used to treat cystic fibrosis (CF), is now listed in the provinces of Ontario, Alberta, and Saskatchewan.
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Has Trikafta been approved in Canada?

TORONTO, April 20, 2022 – The Canadian cystic fibrosis community is celebrating today as Health Canada approves the life-changing cystic fibrosis drug, Trikafta, for children aged six to 11 with at least one F508del gene mutation.
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