Does metformin cause joint and muscle pain?

Conclusions: People with diabetes taking metformin were less likely to report back, knee, neck/shoulder and multisite musculoskeletal pain than those not taking metformin. Therefore, when treating these patients, clinicians should be aware that metformin may contribute to fewer reports of musculoskeletal pain.

Can metformin cause body aches and pains?

One of the rarest side effects is lactic acidosis, a condition in which there's an imbalance in the acid-base levels in your body. “This can present with muscle aches, pain, fatigue, chills, dizziness, drowsiness; very vague symptoms,” says Rodriguez.

Does metformin affect your joints?

Conclusions. Metformin attenuates osteoarthritis structural worsening and modulates pain, suggesting its potential for osteoarthritis prevention or treatment.

Is muscle pain a side effect of metformin?

Symptoms of lactic acidosis include abdominal or stomach discomfort, decreased appetite, diarrhea, fast or shallow breathing, a general feeling of discomfort, severe muscle pain or cramping, and unusual sleepiness, tiredness, or weakness.

Can metformin cause inflammation in the body?

Metformin exhibits an anti-inflammatory action in cells and patients, in addition to its known antihyperglycemic effects.

Metformin Side effects | Tips to Avoid

Does metformin give you arthritis?

Preclinical studies have shown that metformin has anti-arthritis, anti-inflammatory effects through several mechanisms including suppression of osteoclasts gene expression, down-regulation of IL-17-producing Th17 cells, up-regulation of Treg cells and lowering the production of pro-inflammatory cytokines (Kang et al., ...

What are the two most common side effects of metformin?

How do I stop the pain from metformin?

What diabetes medicine causes joint pain?

The class of drugs in question are DPP-4 inhibitors. These are marketed under the names of Januvia, Janumet, Janumet XR, Onglyza, Kombiglyze XR, Tradjenta, Glyxambi, Jentadueto, Nesina, Kazano, Oseni.

Can metformin cause severe leg pain?

Taking the popular type 2 diabetes drug metformin for a prolonged period, and at higher doses, was linked to a higher risk for severe and painful diabetic peripheral neuropathy in a new study published in the journal Scientific Reports.

What does metformin do to your bones?

Therefore, glycemic control in diabetic patients is vital for bone health. Metformin, a widely used antidiabetic drug, has been shown to improve bone quality and decrease the risk of fractures in patients with diabetes in addition to glycemic control and improving insulin sensitivity.

What body system does metformin affect the most?

Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood.

How do you treat diabetic joint pain?

Treatment involves exercising, maintaining a healthy weight, caring for and resting the affected joint, physical therapy, and medications for pain. Treatment may also include surgery such as knee or hip replacement. Complementary treatments — such as acupuncture and massage — also may be helpful for managing pain.

What happens if you stop metformin suddenly?

If you stop taking metformin abruptly, your health may suffer. You may experience side effects such as higher blood sugars, an increased A1c, and even weight gain. Over time, higher blood sugar levels can lead to diabetes complications, including: Retinopathy and blindness.

What is an alternative to metformin?

When should I stop taking metformin?

It is recommended that metformin should be discontinued once eGFR falls below 30 ml/min/1.73 m² and to decrease the metformin dose in mild to moderate renal impairment (eGFR 30–60 ml/min/1.73 m²).

Why do my joints all of a sudden hurt?

Sudden pain in all the joints can be a symptom of several conditions, including infections, gout, ME/CFS, and some autoimmune conditions. It can also be an indication of complications after an illness, such as post-viral syndrome or reactive arthritis.

What medication causes severe joint pain?

Can diabetes make all your joints hurt?

According to the American Arthritis Foundation, people with diabetes are twice as likely to develop arthritis and debilitating joint pain if the condition is unmanaged. Other factors related to diabetes—such as arterial disease, obesity, and diabetic neuropathy—also heighten your chances of suffering from joint pain.

What foods should I avoid on metformin?

As much as possible, avoid white bread, white rice, white pasta, candy, soda, desserts, and snacks like chips or crackers. Eating foods that can spike your blood sugar will not necessarily make the metformin not work, however, it will increase the burden it has to work against.

What is the best joint supplement for diabetics?

WebMD lists glucosamine, chondroitin, vitamin D, and omega-3 fish oils as potentially useful for joint pain. According to Mahsa Tehrani, MD, methylsulfonylmethane (MSM) has been shown in studies to reduce joint-related pain and disability. She also reports that ginger extract helps both pain and stiffness.

How do diabetics get rid of inflammation?

Weight loss and increased physical activity can have strong anti-inflammatory effects and both are important for reducing the risk of type 2 diabetes. Foods with natural anti-inflammatory properties include: Healthy fats like omega-3 fatty acids, olive oil, flaxseed oil, and canola oil. Avocados.

Can diabetes cause inflammation in joints?

According to the Center for Disease Control and Prevention, 47 percent of people with arthritis also have diabetes. Diabetes causes inflammation in the body, which affects the joints as well. Certain forms of arthritis may be more common in people with certain types of diabetes.

What organs does metformin damage?

The kidneys process and clear the medication out of your system through your urine. If your kidneys don't function properly, there's concern that metformin can build up in your system and cause a condition called lactic acidosis. Lactic acidosis is when there's a dangerous amount of lactic acid in the body.

Which groups of patients should not take metformin and why?

Metformin should be avoided in patients with acute or unstable heart failure because of the increased risk of lactic acidosis. It also should be avoided in patients with hepatic impairment, according to the labeling.