Why is clopidogrel given in myocardial infarction?

Clopidogrel reduces the risk of death and cardiovascular complications in patients with symptomatic atherosclerotic disease, in the setting of percutaneous coronary intervention (PCI), and in patients with unstable angina or non-STEMI.
Takedown request   |   View complete answer on academic.oup.com


Why is aspirin and clopidogrel used together for MI?

The combination of clopidogrel and aspirin may lower the risk for major ischemic events among patients with minor ischemic stroke or high-risk transient ischemic attack compared with aspirin alone, according to results of the POINT study.
Takedown request   |   View complete answer on healio.com


Why is it important that clopidogrel and aspirin are given as soon as an acute myocardial event has happened?

Aspirin combined with clopidogrel can effectively reduce the occurrence of re-thrombosis after PCI and improve the recovery of cardiac function after acute operation, moreover the safety is high.
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


How does clopidogrel work in ACS?

Clopidogrel (thienopyridine) inhibits adenosine 5'-diphosphate (ADP)–dependent activation of the glycoprotein IIb/IIIa complex, a necessary step for platelet aggregation. This process results in intense inhibition of platelet function, particularly in combination with aspirin.
Takedown request   |   View complete answer on medscape.com


When do you give clopidogrel in STEMI?

  1. Clopidogrel should be given at a loading dose of 300 mg or 600 mg for ST-segment elevation myocardial infarction (STEMI) as effects are not visible until 4–6 hours after administration.
  2. The degree of platelet inhibition is often not substantial by the time of intervention because of prolonged drug absorption.
Takedown request   |   View complete answer on internationaljpp.com


What is Clopidogrel?



Is clopidogrel used for myocardial infarction?

Clopidogrel is FDA approved for the medical management of unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI), ST-segment elevation myocardial infarction (STEMI) in patients receiving fibrinolytic therapy, and for secondary prevention in recent myocardial infarction (MI), recent stroke, and ...
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


Why are Antiplatelets used in MI?

Antiplatelet drugs play a crucial role in the treatment of patients with myocardial infarction, particularly in association with percutaneous coronary intervention. Their main advantage is the reduction of adverse ischemic incidents and the major disadvantage is the increase in the frequency of hemorrhages.
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


What is the mechanism of action of clopidogrel?

Mechanism Of Action

Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.
Takedown request   |   View complete answer on rxlist.com


What is clopidogrel used for?

About clopidogrel

It prevents platelets (a type of blood cell) from sticking together and forming a dangerous blood clot. Taking clopidogrel helps prevent blood clots if you have an increased risk of having them. Your risk is higher if you have or have had: a heart attack.
Takedown request   |   View complete answer on nhs.uk


What is the first line treatment for a patient with a myocardial infarction?

The early treatment of acute myocardial infarction consists of ensuring the patient is in an environment in which defibrillation is possible and then reducing the size of the potential infarct by re-opening the occluded coronary artery.
Takedown request   |   View complete answer on nps.org.au


What is the drug of choice for myocardial infarction?

The pain of myocardial infarction is usually severe and requires potent opiate analgesia. Intravenous diamorphine 2.5–5 mg (repeated as necessary) is the drug of choice and is not only a powerful analgesic but also has a useful anxiolytic effect.
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


Is clopidogrel a COX inhibitor?

Aspirin (ASA) and clopidogrel have been identified as standard of care in the prevention of major cardiovascular events. Aspirin irreversibly inhibits the cyclooxygenase-1 (COX-1) enzyme, whereas non-steroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit the COX-1 enzyme.
Takedown request   |   View complete answer on pubmed.ncbi.nlm.nih.gov


Why is aspirin given in myocardial infarction?

Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardial infarction, stroke or cerebral ischaemia, peripheral arterial disease ...
Takedown request   |   View complete answer on hindawi.com


What's the difference between aspirin and clopidogrel?

What is the difference between aspirin and Plavix (clopidogrel)? Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots. Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID).
Takedown request   |   View complete answer on medicinenet.com


When do you take clopidogrel instead of aspirin?

Clopidogrel is another guideline‐recommended antiplatelet agent21 and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).
Takedown request   |   View complete answer on ahajournals.org


Is clopidogrel A anticoagulant?

Plavix (clopidogrel bisulfate) and Coumadin (warfarin) are anticoagulants (blood thinners) used to treat patients with acute coronary syndrome, heart attack (myocardial infarction), peripheral vascular disease, and ischemic strokes.
Takedown request   |   View complete answer on rxlist.com


What is clopidogrel used for and what are the side effects?

Clopidogrel is used alone or with aspirin to prevent serious or life-threatening problems with the heart and blood vessels in people who have had a stroke, heart attack, or severe chest pain.
Takedown request   |   View complete answer on medlineplus.gov


How does aspirin and clopidogrel work?

Aspirin and clopidogrel exert their antiplatelet effects by inhibiting thromboxane A2 production and adenosine diphosphate–induced platelet aggregation pathways, respectively. Aspirin has proven benefits in primary and secondary prevention of coronary artery disease.
Takedown request   |   View complete answer on jamanetwork.com


Is clopidogrel a Pgp inhibitor?

Clopidogrel. Clopidogrel is a substrate for P-gp. Inhibition of P-gp activity by different modulators increased the absorptive clopidogrel flux by a maximum of 5- to 9-fold (p < 0.001) over baseline, increasing intracellular accumulation from 0.99 ± 0.11 pmol/mg protein by up to 2.5-fold (p < 0.001) (42).
Takedown request   |   View complete answer on sciencedirect.com


What is the pharmacokinetics of clopidogrel?

In the liver, approximately 15% of absorbed clopidogrel is metabolized by the cytochrome P450 (CYP) system to generate its active metabolite via a 2-step bioactivation process, whereas the rest 85% is hydrolyzed by carboxylesterase 1 (CES1) to an inactive carboxylic acid derivative.
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


Why are anticoagulants used in MI?

Anticoagulation in conjunction with antiplatelet therapy is central to the management of acute coronary syndromes (ACS). When used effectively it is associated with a reduction in recurrent ischaemic events including myocardial infarction and stent thrombosis as well as a reduction in death.
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


Why is heparin given for MI?

The roles of heparin and warfarin in reducing morbidity and mortality after acute myocardial infarction (AMI) are reviewed. Full-dose i.v. heparin, with or without thrombolytic therapy, is indicated for the prevention of reinfarction and thromboembolism after AMI.
Takedown request   |   View complete answer on pubmed.ncbi.nlm.nih.gov


What drugs are given after myocardial infarction?

Currently used post-MI drugs with immunomodulatory effects include platelet inhibitors (A), statins (B), beta-blockers (C), and drugs targeting the renin–angiotensin–aldosterone system (D), including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, angiotensin receptor–neprilysin ...
Takedown request   |   View complete answer on ncbi.nlm.nih.gov


Why is nitroglycerin given for MI?

Nitroglycerin remains a first-line treatment for angina pectoris and acute myocardial infarction. Nitroglycerin achieves its benefit by giving rise to nitric oxide, which causes vasodilation and increases blood flow to the myocardium.
Takedown request   |   View complete answer on ncbi.nlm.nih.gov