Where does XIAFLEX injection go?

Xiaflex is injected directly into the "cord" of the affected hand or into a "plaque" of the penis. A healthcare provider will give you this injection.

Where do you inject XIAFLEX?

The dose of XIAFLEX® is 0.58 mg per injection into a palpable cord with a contracture of a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint.

How is XIAFLEX administered?

The dose of XIAFLEX is 0.58 mg per injection administered into a Peyronie's plaque. If more than one plaque is present, inject into the plaque causing the curvature deformity. A treatment course consists of a maximum of 4 treatment cycles.

Is XIAFLEX injection painful?

Pain. Although Xiaflex is not uncomfortable to receive, some patients have significant pain for up to 48 hours after the injection, with rare patients having discomfort beyond this period.

What to expect after XIAFLEX injections?

Pain, swelling, bruising, bleeding, redness, itching at or around the injection site may occur. Swollen, painful areas in the elbow and underarm (swollen lymph nodes) may also occur when this medication is injected in the hand. If any of these effects persist or worsen, tell your doctor promptly.

Optimizing Outcomes with Xiaflex Injections

How fast does XIAFLEX work?

Some men may see improvements after one or two cycles, while men with severe curvatures may benefit more from three or four cycles.

How successful is XIAFLEX?

Studies have shown 34% improvement in penile curvature in men who underwent treatment with Xiaflex injection compared to 18% improvement in men treated with saline injection.

Does XIAFLEX decrease size?

Xiaflex treatment for Peyronie's disease may improve penile curvature degree with no effect on the loss on penile length in post-marketing analysis. Paper presented at 2021 Sexual Medicine Society of North America Annual Meeting; October 21-24, 2021.

How long does XIAFLEX last?

For Peyronie's disease

Your doctor will inject Xiaflex directly into the plaque (fibrous scar tissue) in your penis that's causing it to bend. You may receive a local anesthetic to numb the area first. You may receive up to four cycles of treatment about 6 weeks apart.

Why was XIAFLEX discontinued?

The decision to withdraw is not based on safety or efficacy concerns. Despite best efforts to appropriately educate the government and the market on XIAFLEX® over the past several years, the product did not receive government reimbursement approval and demand for the product has remained unsustainably low.

How do you draw up a XIAFLEX injection?

With the tip of the needle placed within the plaque, initiate injection, maintaining steady pressure to slowly inject XIAFLEX into the plaque. Withdraw the needle slowly so as to deposit the full dose along the needle track within the plaque.

How much do XIAFLEX injections cost?

Doctors who administer the drug will have to be specially trained and certified. Pain, swelling and bruising can develop in the injection area. Xiaflex costs $3,300 an injection, so a full course of eight injections would cost about $26,000, in addition to a doctor's fee.

What does XIAFLEX do for Peyronie's?

Xiaflex is a medication called collagenase clostridium histolyticum. It actively targets the Peyronie's plaque to break it down. While the fibers in the plaque are being broken down, manual stretching and straightening help the penis to regain a more normal shape and decrease the degree of curvature.

Can you drive after XIAFLEX injection?

You will be able to drive yourself home after the appointment. You may use ice as needed for 15-20 minutes to reduce swelling. You may take Tylenol or Ibuprofen as needed for pain.

Is Peyronie's disease permanent?

Peyronie's disease is usually a permanent condition. True Peyronie's disease rarely goes away on its own, but can occasionally change even years after diagnosis in response to further injuries. The changes in the penis can always be improved using a variety of treatments.

Does Peyronie's plaque go away?

Peyronie's disease rarely goes away on its own. In most men with Peyronie's disease, the condition will remain as is or worsen. Early treatment soon after developing the condition may keep it from getting worse or even improve symptoms.

Is there a pill to cure Peyronie's disease?

The U.S. Food and Drug Administration today approved a new use for Xiaflex (collagenase clostridium histolyticum) as the first FDA-approved medicine to treat men with bothersome curvature of the penis, a condition known as Peyronie's disease.

Does insurance cover peyronies?

Medicare and most insurance plans cover the procedure in most cases. Billing specialists in the physician's office can help confirm your coverage.

What is the success rate for Peyronie's disease surgery?

They found the overall success rate of surgery was 96%, compared with 66% with CCH and 48% with traction. At a decade post treatment, traction was the most cost-effective with an average per-patient cost of $883, compared to $11,419 for surgery and $33,628 for CCH.

Does XIAFLEX increase size?

Xiaflex with first generation PTT devices also had not impact on length. When patients used RestoreX along with the injection treatment, they experienced a nearly 2cm gain in length or about 17%.

Is XIAFLEX discontinued?

PRODUCT DISCONTINUATION FROM 28 JUNE 2019

It has provided a non-surgical option for patients with Dupuytren's Contracture and Peyronie's Disease.

Is there a generic for XIAFLEX?

Xiaflex is available in a generic form as collagenase Clostridium histolyticum.

Is there an alternative to xiapex?

Unfortunately, Xiapex has been withdrawn from clinical use for Dupuytren's disease for commercial reasons. This is very disappointing as it was proving to highly effective. Mike is able to offer alternatives including percutaneous needles fasciotomy (PNF) or open surgery.

Why was xiapex withdrawn?

The withdrawal was at the request of the marketing authorisation holder, Swedish Orphan Biovitrum AB (publ), which notified the European Commission of its decision to permanently discontinue the marketing of the product for commercial reasons.