What drugs increase intracranial pressure?

Title: MEDICATIONS THAT INCREASE INTRACRANIAL PRESSURE
  • Nitroprusside. Vasodilates both cerebral arteries and veins, increasing ICP. ...
  • Nitroglycerin. Causes cerebral venodilation, increasing ICP. ...
  • Hydralazine (varying effects) Vasodilates cerebral arteries > cerebral veins. ...
  • Nicardipine.
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What medications cause intracranial pressure?

Medicines known to be associated with IIH include1-4:
  • antibiotics including tetracyclines (eg, minocycline, doxycycline), naldixic acid and nitrofurantoin.
  • steroids (on withdrawal)
  • contraceptives.
  • vitamin A derivatives such as isotretinoin.
  • indomethacin or ketoprofen in patients with Bartter's syndrome.
  • amiodarone.
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What can worsen intracranial pressure?

Increased ICP can result from bleeding in the brain, a tumor, stroke, aneurysm, high blood pressure, or brain infection. Treatment focuses on lowering increased intracranial pressure around the brain.
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What drugs decrease ICP?

Medication Summary

Carbonic anhydrase inhibitors (eg, acetazolamide) and loop diuretics (eg, furosemide) are thought to exert their effect on ICP by reducing cerebrospinal fluid (CSF) production at the choroid plexus. Cardiac glycosides have a similar effect.
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Which of the following medications is associated with IIH?

Vitamin A derivatives, tetracycline-class antibiotics, recombinant growth hormone, and lithium were found to be most strongly associated with DIIH (Categories IV and V). Corticosteroids were moderately associated with DIIH (Category III).
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Increased Intracranial Pressure



Does caffeine make IIH worse?

By contrast, long-term treatment with caffeine increases the threshold for convulsions [13,14]. Moreover, short-term treatment with caffeine worsens ischemia-induced damage [15], whereas, long-term treatment with caffeine reduces such damage [16,17].
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Can antidepressants cause intracranial hypertension?

Selective serotonin reuptake inhibitors and more generally antidepressants acting as strong inhibitors of serotonin reuptake increase the risk for ICH, particularly during the first months of use.
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What drug prevents elevation of intracranial pressure?

Mannitol is the most commonly used hyperosmolar agent for the treatment of intracranial hypertension. More recently, hypertonic saline also has been used in this circumstance.
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What drugs can cause brain swelling?

A research collaboration among researchers at Yale, the University of Tennessee and the University of Cincinnati discovered that an opioid overdose may cause a potentially fatal combination of symptoms, including brain swelling and memory loss, when left untreated.
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What diuretic is used for intracranial pressure?

Osmotic diuretics, (e.g., urea, mannitol, glycerol) and loop diuretics (e.g., furosemide, ethacrynic acid) are first-line pharmacologic agents used to lower elevated ICP.
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What triggers IIH?

Causes of chronic intracranial hypertension

a blood clot on the surface of your brain, known as a chronic subdural haematoma. a brain tumour. an infection in your brain, such as meningitis or encephalitis. hydrocephalus, where fluid builds up around and inside your brain.
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Does caffeine increase intracranial pressure?

Caffeine decreases cerebral blood flow from 10 to 20%. These facts create a theoretical hypothesis that the decrease of CBF may reduce incranial pressure.
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What is one of the earliest signs of increased intracranial pressure?

A: Early signs and symptoms include: changes in mental status, such as disorientation, restlessness, and mental confusion. purposeless movements. increased respiratory effort.
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Can antibiotics cause intracranial hypertension?

That a common antibiotic, doxycycline, used to treat malaria, acne, and other infections could cause increased intracranial pressure is not a recent revelation. Other tetracyclic antibiotics such as minocycline and tetracycline have caused intracranial hypertension.
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Does ibuprofen reduce intracranial pressure?

You may need any of the following: Migraine medicine may help decrease how much CSF you produce. This will help relieve pressure in your skull. NSAIDs , such as ibuprofen, help decrease swelling, pain, and fever.
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Can gabapentin increase intracranial pressure?

Results: The heart rate, mean arterial blood pressure and intracranial pressure decreased significantly with gabapentin as compared to the control group (P < 0.05).
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Can drugs cause fluid on the brain?

Results: Cerebral edema was confirmed in 52 (20.63%) of the drug addicts. The differences between the groups of drug addicts with and without cerebral edema were determined in the following: the time span of taking drugs (0.301), use of alcohol parallel with drugs (0.466), and treatment for addiction (0.603).
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Can opioids cause cerebral edema?

Opioid receptor activation also leads to cerebral edema, with subcellular molecular mechanisms similar to those that produce pulmonary edema.
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Can brain damage caused by drugs be reversed?

According to the National Institute of Health, abstaining from substances for one year can result in a reversal of the structural changes in the brain. Every person will have a different experience with brain healing depending on the substance that was used.
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Does Lasix decrease ICP?

Infusions of large volumes of furosemide even resulted in an increase of ICP, but infusion of 40% sorbitol effected a rapid decrease of ICP and EEG recovery over the left hemisphere.
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What activities increase intracranial pressure?

A head injury may cause increased ICP. Some examples of how a person can reduce their risk of head injury include: avoiding extreme sports or dangerous activities. always wearing a helmet for activities such as riding a bike.
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Does furosemide lower ICP?

Furosemide administration effectively lowers intracranial pressure in newborn preterm and term rabbit pups. This effect may be due to the diuretic action of the drug, its ability to inhibit cerebrospinal fluid production or to a combination of both.
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What medications should be avoided with pseudotumor cerebri?

Medications that are known to precipitate Pseudotumor CEREBRI (PTC) and should be AVOIDED:
  • Tetracycline, Doxycycline, Minocycline (usually prescribed for treatment of Acne and Rosacea)
  • Vitamin A and related compounds: ...
  • Growth Hormone (rHGH, synthetic)
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Can steroids cause IIH?

Abstract. Benign intracranial hypertension (BIH, pseudotumour cerebri) is a rare condition with unknown aetiology although hormonal influences have been implicated. It occurs spontaneously, particularly in young obese women, and is associated with several drug treatments including corticosteroids.
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What vitamins help with IIH?

Introduction. Vitamin A and its metabolites (called retinoids) have been thought to play a role in the development of idiopathic intracranial hypertension (IIH).
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