What are the three phases of Paget's disease?

The key histopathological feature of Paget disease involveS the bone architecture and includes the three phases of the disease: mixed, osteolytic, and osteosclerotic. These phases may occur at the same time or separately.
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How many types of Paget's disease are there?

What are the types of Paget's disease? There are two types of Paget's disease of bone: When a single site of bone is affected by Paget's disease, it is referred to as the monostotic type. When multiple sites of bone are affected by Paget's disease, it is referred to as the polyostotic type.
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What is lytic phase of Paget's disease?

Paget disease begins with the lytic phase, in which normal bone is resorbed by osteoclasts that are more numerous, are larger, and have many more nuclei (up to 100) than normal osteoclasts (5-10 nuclei). Bone turnover rates increase to as much as 20 times normal.
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What is osteosclerotic phase?

a mixed lytic and sclerotic phase - osteoblasts lay down woven bone which is subsequently resorbed by osteoclasts. a burnt out quiescent osteosclerotic stage - osteoclasts are less active and the eroded areas are filled with brittle, woven bone.
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What are characteristics of Paget's disease?

Early symptoms of Paget's disease include bone pain, joint pain (especially in the back, hips and knees), and headache. Physical signs include enlargement and bowing of the thighs (femurs) and lower legs (tibias), and enlargement of the skull in the area of the forehead.
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Paget Disease: Osmosis Study Video



How many stages does Paget's disease have?

The key histopathological feature of Paget disease involveS the bone architecture and includes the three phases of the disease: mixed, osteolytic, and osteosclerotic. These phases may occur at the same time or separately.
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What of the following is the most common appearance of Paget's disease?

Paget's disease can affect any bone in the skeleton. It appears most often in the spine, pelvis, long bones of the limbs, and skull. It can be present in just one bone or in several bones.
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What is the pathology of Paget's disease?

Pathology. Paget's disease is a focal disorder of skeletal remodeling in which the primary cellular abnormality is an increase in osteoclastic resorption of bone (Fig. 1). Increased bone resorption leads to a compensatory increase in bone formation.
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Why is calcium and phosphate normal in Paget's disease?

Calcium and phosphate — The breakdown and buildup of bone is essential in regulating the levels of calcium and phosphorus in the blood. In most people with Paget disease, these levels remain normal. (See "Patient education: Primary hyperparathyroidism (Beyond the Basics)".)
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What is the differential diagnosis of Paget's disease?

The differential diagnosis of Paget disease includes osteomalacia, which may be part of the spectrum of osseous abnormalities accompanying chronic renal insufficiency. Patients with mild osteomalacia may present with nonspecific bone pain and tenderness.
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What is the first line treatment for Paget disease?

Bisphosphonates are first-line therapy for Paget's disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment.
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Which of the following diagnostic tests confirms Paget's disease?

Bone scan. This is the best test for diagnosing Paget's disease. You may have a bone scan of your whole body to find out which bones are affected. Blood and urine tests.
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What is Polyostotic Pagets disease?

Any of your bones can be affected by Paget's disease. However, your pelvis, skull, spine and leg bones (femur and tibia) are most commonly affected by Paget's disease. Paget's disease can affect one bone (monoostotic) or many bones (polyostotic).
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What are the four most common areas affected by Paget's disease?

The disease might affect only one or two areas of your body or might be widespread.
...
Symptoms
  • Pelvis. Paget's disease of bone in the pelvis can cause hip pain.
  • Skull. An overgrowth of bone in the skull can cause hearing loss or headaches.
  • Spine. ...
  • Leg.
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How quickly does Paget's disease progress?

Mammary Paget's disease is associated with carcinoma of the underlying lactipherous ducts. The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue.
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What is the most common age to be diagnosed with Paget's disease?

Paget's disease of the breast occurs most often after age 50. Most people with this diagnosis also have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer.
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How high is ALP in Pagets?

We can see that localized forms of Paget's disease may have an alkaline phosphatase activity of 2 000 or 3 000 I.U., while the AP levels in the blood are less than 200.
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Does vitamin D deficiency cause Paget's disease?

Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls. Arq Bras Endocrinol Metabol. 2013 Oct;57(7):509-12. doi: 10.1590/s0004-27302013000700002.
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What is the life expectancy of someone with Paget's disease of the bone?

In that study, the British General Practice Research Database identified 2465 patients diagnosed with Paget's disease of bone from 1988 to 1999; retrospective review indicated that 5-yr survival was 67% in patients with Paget's disease compared with 72% in control patients.
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What are the long term effects of Paget's disease?

If Paget's disease of bone affects the skull, there's a significant risk that it could lead to permanent hearing loss and possibly total deafness. This can occur as a result of damage to the bones or nerves that connect the ears to the brain.
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What is the best treatment for Paget's disease?

Osteoporosis drugs (bisphosphonates) are the most common treatment for Paget's disease of bone. Bisphosphonates are typically given by injection into a vein, but they can also be taken by mouth. When taken orally, bisphosphonates are generally well tolerated but can irritate the stomach.
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Is Pagets disease fatal?

The disease may cause fractures, bowed legs, a curved spine or pinched nerves in the spine. Over time, enlarged or misshapen bones can stress nearby joints leading to osteoarthritis in those joints. In very rare cases, Paget's can turn into a life-threatening cancerous bone disease.
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What does early Paget's disease look like?

Symptoms of Paget's disease of the nipple

Paget's disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation.
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How can you tell the difference between Paget's disease and eczema?

Paget's disease may affect your nipple, while eczema rarely affects your nipple. Paget's disease also typically only affects one breast, while eczema affects both breasts and other parts of your chest. Paget's disease won't respond to the same treatments as eczema.
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Does Paget's disease cause pain?

Symptoms of Paget's disease of bone include bone pain, joint pain and problems caused by a nerve being squashed or damaged. But in many cases, there are no obvious symptoms and the condition is only found during tests carried out for another reason. 1 bone or several bones may be affected.
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