What are the symptoms of Kleine Levin syndrome?

Symptoms occur as "episodes," typically lasting a few days to a few weeks. Episode onset is often abrupt, and may be associated with flu-like symptoms. Excessive food intake, irritability, childishness, disorientation, hallucinations, and an abnormally uninhibited sex drive may be observed during episodes.
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What symptoms might lead a doctor to suspect a patient has Kleine-Levin syndrome?

Kleine-Levin syndrome is an extremely rare disorder characterized by the need for excessive amounts of sleep (hypersomnolence), excessive eating (compulsive hyperphagia), and behavioral abnormalities. Onset of symptoms associated with this disorder is extremely rapid. Such symptoms may persist for days to weeks.
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What are the symptoms of KLS?

Kleine-Levin syndrome (KLS) is a rare disorder that causes recurring periods of excessive sleepiness. In some cases, this means up to 20 hours a day are spent sleeping.
...
What are the symptoms?
  • hallucinations.
  • disorientation.
  • irritability.
  • childish behavior.
  • increased appetite.
  • excessive sex drive.
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How long do KLS episodes last?

While KLS episodes are most closely associated with large amounts of sleep, they can also bring about specific behavioral changes, increased hunger, and hypersexuality. Each episode can last a minimum of a week and a maximum of two months.
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How do you treat Kleine Levin?

Treating Kleine-Levin Syndrome

There is no specific, definitive treatment to cure or control KLS. Some aspects of the disease can be managed with medication, such as stimulants to combat the EDS, but this is most effective only once the episodes have already decreased in severity.
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Kleine Levin Syndrome (KLS) | Causes, Symptoms



How is KLS diagnosed?

To be diagnosed with KLS, a person must meet first the criteria for recurrent hypersomnia: Episodes of excessive sleepiness lasting between two days and five weeks. Episodes occur at least once every 18 months and often more frequently. Normal behavior and cognition between episodes.
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How many people are affected by Kleine-Levin syndrome?

Kleine-Levin syndrome (KLS) is a rare disorder with an estimated prevalence of one to five cases per million population [2-8]. Patients with primary KLS can be found worldwide, with a higher prevalence among Ashkenazi Jews.
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What is the exploding head syndrome?

Exploding head syndrome (EHS) is a type of sleep disorder in which you hear a loud noise or explosive crashing sound in your head. The sound isn't real or heard by anyone else. The episode typically happens suddenly either when you're beginning to fall asleep or when you wake up during the night.
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How common is sleeping beauty syndrome?

Scientists estimate that the syndrome manifests in 1 to 5 people out of every million, according to the clinical resource UpToDate. Historically, more than 500 cases of the condition have been reported in the medical literature, although the unusual syndrome likely goes underdiagnosed.
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What are the 5 types of sleep disorders?

Thankfully, there are treatments available that you can talk to your patients about for the five most common sleep disorders:
  • Insomnia.
  • Sleep Apnea.
  • Narcolepsy.
  • Restless Legs Syndrome.
  • and REM Sleep Behavior Disorder.
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What is the outcome of KLS patients?

Many patients reported amnesia of the events that occurred during an attack. Between episodes, majority of patients were described as totally normal. In a few cases reported, academic decline and a mild, long-lasting memory dysfunction between episodes.
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What psychological disorder does Sleeping Beauty have?

Kleine–Levin syndrome (KLS), also called “Sleeping beauty syndrome” is a rare disorder characterized by recurrent episodes of hypersomnia and to various degrees, hyperphagia, cognitive disturbances, and hypersexuality.
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What is parasomnia?

Parasomnias are disruptive sleep-related disorders. Abnormal movements, talk, emotions and actions happen while you're sleeping although your bed partner might think you're awake. Examples include sleep terrors, sleepwalking, nightmare disorder, sleep-related eating disorder and sleep paralysis.
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Why do I hear loud knocking in my sleep?

What's exploding head syndrome? Exploding head syndrome is a condition that happens during your sleep. The most common symptom includes hearing a loud noise as you fall asleep or when you wake up. Despite its scary-sounding name, exploding head syndrome usually isn't a serious health problem.
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Why do I hear weird noises at night?

Summary. Hearing voices at night is not uncommon. While it can be a sign of a mental health condition such as schizophrenia, it is also seen when sleep is disrupted, after stress or trauma, or with certain medications or medical conditions.
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Is Kleine-Levin syndrome genetic?

Kleine-Levin syndrome (KLS) is a rare periodic hypersomnia with associated behavioural abnormalities but with often favourable prognosis. There is excess risk of KLS in first-degree relatives, suggesting a strong genetic contribution.
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Is there a condition where you can only sleep during the day?

Narcolepsy is a neurological sleep disorder characterized by chronic, excessive attacks of drowsiness during the day, sometimes called excessive daytime sleepiness (EDS).
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What is Omnia disease?

Sexsomnia is recognised as a rare sleep disorder in which a person engages in sexual activity during their sleep. In general they'll have no recollection of events during the act or when they wake up.
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What is a Dyssomnia?

Dyssomnia refers to the collection of sleep disorders that negatively impact the quantity and quality of sleep2. With dyssomnia, you might struggle to fall asleep at night3, which is a symptom of insomnia, or feel the need to sleep excessively, which is called hypersomnolence.
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What is cataplexy a symptom of?

Cataplexy is associated with narcolepsy. Narcolepsy is a neurological condition that causes extreme sleepiness during the day. You can also have unexpected episodes of falling asleep, even in the middle of a conversation or in the middle of an activity.
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When was Kleine-Levin syndrome discovered?

Critchley [5] provided the essence of the syndrome in 1962: 'Thirty-three years ago a syndrome of “morbid hunger and periodic somnolence” was first extracted out of the amorphous and miscellaneous groups of cases of pathological sleep. Twenty years ago it first received the status of the “Kleine–Levin syndrome”.
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What disease makes you sleep a lot?

Overview. Narcolepsy is a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden attacks of sleep. People with narcolepsy often find it difficult to stay awake for long periods of time, regardless of the circumstances.
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What is the number one sleep disorder?

Insomnia - being unable to fall asleep and stay asleep. This is the most common sleep disorder.
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What are the 3 most common sleep disorders?

The top ones are: Insomnia. Sleep apnea. Restless legs syndrome.
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Why do I sleep all day and stay up all night?

Hypersomnia is excessive sleepiness. There are many causes of excessive sleepiness, including insufficient or inadequate sleep, sleep disorders, medications and medical or psychiatric illnesses. The characteristics of hypersomnia vary from one person to the next depending on age, lifestyle and underlying causes.
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