How do human males with XXY abnormality suffer?

As babies and children, XXY males may have weaker muscles and reduced strength. As they grow older, they tend to become taller than average. They may have less muscle control and coordination than other boys of their age.

What happens when a man has XXY chromosomes?

Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue.

What is Klinefelter syndrome and how would it affect the male reproductive system?

Boys and men with Klinefelter syndrome typically have small testes that produce a reduced amount of testosterone (primary testicular insufficiency). Testosterone is the hormone that directs male sexual development before birth and during puberty.

How will you describe the condition of a person with Klinefelter syndrome?

Klinefelter syndrome is a common genetic condition where a male is born with an extra X chromosome. Typically, a male has one X and one Y chromosome. People with Klinefelter syndrome can experience breast growth, breast cancer, osteoporosis, infertility and learning difficulties.

How common is XXY male syndrome?

Affected Populations. 47, XXY (KS) is the most common human sex chromosome disorder and occurs in approximately 1 in 500-1,000 males.

Chromosomal Abnormalities: Turner, Klinefelter

What does an XXY person look like?

As XXY males enter puberty, they may have a taller, less muscular body, less facial and body hair, and broader hips than other boys. As teens, XXY males may have larger breasts, weaker bones, and a lower energy level than other boys.

Which of the following is most likely a characteristic of a person with Klinefelter syndrome?

What are the symptoms of Klinefelter syndrome? Males who have Klinefelter syndrome may have the following symptoms: small, firm testes, a small penis, sparse pubic, armpit and facial hair, enlarged breasts (called gynecomastia), tall stature, and abnormal body proportions (long legs, short trunk).

Does Klinefelter syndrome affect lifespan?

Prognosis for Klinefelter Syndrome

In general, life expectancy is normal. Some research has found that life expectancy for men with the condition may be a year or two less than those without it because of other health problems linked to Klinefelter.

Why does Klinefelter syndrome only occur in males?

It's a genetic condition (meaning a person is born with it). Klinefelter syndrome only affects males. It happens because of a difference deep inside the body's cells, in microscopic strings of DNA (what make up genes) called chromosomes.

Is Klinefelter syndrome a disability?

Most males with the 47,XXY karyotype have normal intelligence. Intellectual disability occurs in males with Klinefelter syndrome variants, who have a higher number of X chromosomes. About 70% of patients have minor developmental and learning disabilities.

Do men with Klinefelter's have low testosterone?

In patients with Klinefelter's syndrome, blood tests characteristically show a low testosterone level, high sex hormone binding globulin (SHBG) and raised gonadotrophins. The diagnosis of Klinefelter's syndrome is confirmed by chromosomal analysis (karyotyping), which involves a blood test.

Can a man with Klinefelter syndrome have babies naturally?

It is possible that an XXY male could get a woman pregnant naturally. Although sperm are found in more than 50% of men with KS³, low sperm production could make conception very difficult.

Can males with Klinefelter syndrome have babies?

Until 1996, men with Klinefelter syndrome were considered infertile. Since then, however, developments in microsurgical techniques and advances in artificial reproductive technologies (ART) have enabled over 50% of men with Klinefelter syndrome to sire their own children.

What would you expect for an individual with the genotype XXY?

Males with XXY syndrome are born with cells that have an extra X chromosome, or XXY. This can cause delayed development and puberty, a smaller penis and testicles, infertility, and other symptoms. The condition that causes XXY syndrome is present at birth and can't be changed.

Why does an extra chromosome cause problems?

A change in the number of chromosomes can cause problems with growth, development, and function of the body's systems. These changes can occur during the formation of reproductive cells (eggs and sperm), in early fetal development, or in any cell after birth.

What are interesting facts about Klinefelter syndrome?

Klinefelter syndrome results when a boy is born with at least 1 extra X chromosome. This is written as XXY. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.

What is the genotype of a person suffering from Klinefelter's syndrome?

In 1959, these men with Klinefelter syndrome (KS) were discovered to have an extra X chromosome (genotype XXY) instead of the usual male sex complement (genotype XY).

Is XXY an intersex condition?

Therefore, according to the NZKA, not all XXY individuals will develop Klinefelter Syndrome, for the Syndrome is simply a form of male hypogonadism, caused by a lack of testosterone: thus XXY is not an intersex condition.

Can females have XXY syndrome?

Klinefelter syndrome affects males only; females cannot have it. Klinefelter syndrome results from a genetic abnormality in which males have an extra copy of the X chromosome. Instead of the usual XY chromosomes, males with Klinefelter syndrome have an XXY pattern.

Does Klinefelter syndrome affect fertility?

Main Points. Klinefelter syndrome (KS) is the most common chromosomal disorder in men and is associated with hypergonadotropic hypogonadism and infertility.

Which parent does Klinefelter's syndrome originate from?

Although Klinefelter syndrome is a genetic condition, it is not hereditary or inherited from the parents. Instead, it is believed to occur due to a random error during the cell division of the sperm or egg cell that is responsible for giving rise to the the fetus.

Can you be short with Klinefelter syndrome?

Although one of the most characteristic features of Klinefelter syndrome is tall stature, some uncommon variants are associated with short stature (49 XXXXY, isochromosome Xq) [3–5]. To the knowledge, there are few reported cases of Klinefelter syndrome and short stature secondary to growth hormone deficiency [1, 4].

What does an extra Y chromosome do?

The extra X and/or Y chromosome can affect physical, developmental, behavioral, and cognitive functioning. Common physical features may include tall stature, lack of secondary pubertal development, small testes (hypogonadism), delayed pubertal development, and breast development (gynecomastia) in late puberty.

Does Klinefelter syndrome make you tired?

They may have weak muscles. Many feel tired a lot of the time and sleep a great deal. Men with Klinefelter may also develop other diseases and disorders.

Does Klinefelter syndrome affect mental health?

Patients with Klinefelter syndrome have a higher burden of psychiatric conditions, especially depression, anxiety, schizophrenia and psychosis, than the general population. Adolescents are described as being sensitive, introspective and unassertive.